Analysis of efficacy and safety of intensity-modulated radiotherapy with “Target-Ring” strategy for stage IVA large-volume thymoma and thymic carcinoma: a single-center study

Background: Thymic tumors at stage IVA are characterized by local invasion into adjacent structures (e.g., pericardium, great vessels) and/or regional lymph node metastasis, with unresectable large-volume tumors posing unique therapeutic challenges due to their proximity to critical thoracic organs and potential for high tumor burden. Additionally, previous studies have shown that conventional rad…