FLT3-ITD MUTATION PROMOTES LEUKEMIC DIFFERENTIATION TOWARDS …
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- DOI 10.1016/j.htct.2025.104544
- OpenAlex ID W4415669058
- Type Article
- Language EN
- Published 01 Oct 2025
- Volume 47
- Pages 104544
- Source Hematology Transfusion and Cell Therapy
- Publisher Elsevier BV
- Countries 2
- Institutions 10
- Added 29 Oct 2025
- Updated 26 Sep 2026
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FLT3-ITD MUTATION PROMOTES LEUKEMIC DIFFERENTIATION TOWARDS AN IMMATURE CYTOTOXIC STAGE
Article 2025 EN Diamond
FLT3 mutations drive leukemogenesis and poor prognosis in acute myeloid leukemia (AML). Despite targeted therapies, high relapse rates persist, likely due to FLT3-ITD–mediated stem cell survival and immune evasion. This study aimed to investigate how FLT3-ITD burden and clonal dominance influence immune status and treatment response. NK and T cells were assessed by flow cytometry in a Flt3-ITD kno…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
20 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | AG Carvalho | — | — |
| 2 | M Medeiros | — | — |
| 3 | CAB Garcia | — | — |
| 4 | LS Binélli | — | — |
| 5 | Álvaro Percínio Costa | University of Alabama (US) University of Alabama at Birmi… (US) | |
| 6 | BL Adjafre | — | — |
| 7 | L Marani | — | |
| 8 | PS Scheucher | Universidade de São Paulo (BR) | — |
| 9 | JLS Schiavinato | Universidade de São Paulo (BR) | — |
| 10 | MIA Madeira | Universidade de São Paulo (BR) | — |
| 11 | JA de Paula | — | — |
| 12 | KBB Pagnano | Universidade Estadual de Campi… (BR) | |
| 13 | BKL Duarte | Universidade Estadual de Campi… (BR) | — |
| 14 | ABF Glória | Universidade Federal de Minas … (BR) Hospital das Clínicas da Unive… (BR) | — |
| 15 | EC Nunes | Hospital de Clínicas Universid… (BR) Universidade Federal do Paraná (BR) | |
| 16 | Marcia Higashi | Hospital Amaral Carvalho (BR) | |
| 17 | WFS Júnior | Instituto do Câncer do Estado … (BR) | — |
| 18 | F Traina | — | — |
| 19 | Eduardo Magalhães Rego | Universidade de São Paulo (BR) | |
| 20 | LL Figueiredo-Pontes | — | — |
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