Meropenem dosing optimization on day 1 and steady state in c…

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Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment

Article 2025 EN Gold

This study aimed to characterize meropenem pharmacokinetics and optimise dosing for the initial and steady state in critically ill patients. Adult patients receiving meropenem were recruited, with sampling performed on days 1 (Occasion 1) and 3 (Occasion 2) of therapy. A composite target of free drug concentrations above the minimum inhibitory concentration for the entire dosing interval (100%ƒT >…

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13 authors
#AuthorInstitutionsORCID
1 Helmi Sulaiman University of Malaya (MY)
2 Muhammad Azrai Rozali International Islamic Universi… (MY) —
3 Santosh Kumar Sreevatsav Adiraju The University of Queensland (AU)
4 Mohd Shahnaz Hasan University of Malaya (MY)
5 Janattul‐Ain Jamal Universiti Teknologi MARA Syst… (MY) Universiti Teknologi MARA (MY)
6 Xin Liu The University of Queensland (AU)
7 Mohd Basri Mat Nor International Islamic Universi… (MY)
8 Mohd Zulfakar Mazlan Universiti Sains Malaysia (MY) Hospital Universiti Sains Mala… (MY)
9 Mohamad Irfan Othman Jailani University of Malaya (MY) —
10 Zeti Norfidiyati Salmuna Universiti Sains Malaysia (MY) Hospital Universiti Sains Mala… (MY) —
11 Steven C. Wallis The University of Queensland (AU)
12 Jason Alexander Roberts The University of Queensland (AU) Université de Montpellier (FR) +3
13 Mohd Hafiz Abdul-Aziz Corresponding The University of Queensland (AU)

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