Ageing-Related Changes in Ultrastructural Bone Matrix Compos…

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Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity

Review 2025 EN Hybrid

PURPOSE OF REVIEW: Bone matrix is a multiscale composite material mainly composed of collagen, crystalline apatite mineral, water, and a small amount of non-collagenous proteins. Nested within bone matrix, mechanosensitive osteocytes orchestrate bone adaptation to mechanical loading, which is affected by the ultrastructural composition and mechanical properties of the osteocyte-surrounding bone ma…

16

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141

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3

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3.54

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3 authors
#AuthorInstitutionsORCID
1 Yunxin Chen Academic Center for Dentistry … (NL) Amsterdam University Medical C… (NL) +4
2 Jenneke Klein‐Nulend Academic Center for Dentistry … (NL) Amsterdam Movement Sciences (NL) +2
3 Nathalie Bravenboer Corresponding Amsterdam University Medical C… (NL) Amsterdam Movement Sciences (NL) +2

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