HIF-1α Stabilization Hampers the Chondrogenic Differentiatio…

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  • DOI 10.1021/acsptsci.5c00190
  • PMID https://pubmed.ncbi.nlm.nih.gov/40672664
  • OpenAlex ID W4411586081
  • Type Article
  • Language EN
  • Published 24 Jun 2025
  • Volume 8 (7)
  • Pages 2075–2092
  • Source ACS Pharmacology & Translational Science
  • Publisher American Chemical Society
  • FWCI 2.57
  • Countries 2
  • Institutions 5
  • Added 10 Oct 2025
  • Updated 01 Oct 2026
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HIF-1α Stabilization Hampers the Chondrogenic Differentiation of Aged Bone Marrow Mesenchymal Stem Cells by Adenosine A 2A /A 2B Receptors Imbalance

Article 2025 EN Hybrid

High Resolution Image Download MS PowerPoint Slide Trauma and excessive motion are deleterious to cartilage by triggering HIF-1α stabilization, leading to changes in extracellular adenosine formation via CD73. How these changes affect adenosine A 2A /A 2B receptors activation balance in chondrogenesis is unclear. We used bone marrow mesenchymal stem cells (BM-MSCs) from aged women to investigate t…

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13 authors
#AuthorInstitutionsORCID
1 Rui Pinto-Cardoso Universidade do Porto (PT) Centro de Investigação Farmaco… (PT)
2 Catarina Bessa-Andrês Universidade do Porto (PT) Centro de Investigação Farmaco… (PT)
3 Flávio Pereira-Costa Universidade do Porto (PT) Centro de Investigação Farmaco… (PT)
4 Rafael Neiva Universidade do Porto (PT) Centro de Investigação Farmaco… (PT)
5 Ricardo Martins-Ferreira Universidade do Porto (PT) Instituto de Ciências Biomédic… (PT)
6 Bárbara Leal Universidade do Porto (PT) Instituto de Ciências Biomédic… (PT)
7 Diogo Nóbrega Catelas Hospital de Santo António (PT)
8 Adélio Vilaça Hospital de Santo António (PT)
9 António Oliveira Hospital de Santo António (PT)
10 Julie Pelletier Université Laval (CA)
11 Jean Sévigny Université Laval (CA)
12 José Bernardo Noronha‐Matos Universidade do Porto (PT) Centro de Investigação Farmaco… (PT)
13 Paulo Correia‐de‐Sá Corresponding Universidade do Porto (PT) Centro de Investigação Farmaco… (PT)
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