Desiccation-induced DNA damage facilitates drug resistance i…
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- DOI 10.1101/2025.06.04.657859
- PMID https://pubmed.ncbi.nlm.nih.gov/40501622
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/12157685
- OpenAlex ID W4411074790
- Type Preprint
- Language EN
- Published 04 Jun 2025
- Source bioRxiv (Cold Spring Harbor Laboratory)
- Publisher Cold Spring Harbor Laboratory
- Countries 1
- Institutions 6
- Added 06 Jun 2025
- Updated 28 Oct 2026
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Desiccation-induced DNA damage facilitates drug resistance in Mycobacterium tuberculosis
Preprint 2025 EN Green
ABSTRACT Mycobacterium tuberculosis (Mtb) is an obligate human pathogen that depends on its ability to spread from host-to-host to survive as a species. Yet, knowledge of transmission-specific traits remains lacking. Here, we report the discovery of a specific adaptive response to desiccation, a stress intrinsically linked to the generation of the aerosol droplets within which Mtb transmits. We sh…
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20 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | C. D. Brown | Weill Cornell Medicine (US) | — |
| 2 | Brenda Lee | Weill Cornell Medicine (US) | |
| 3 | Han Liu | Weill Cornell Medicine (US) | |
| 4 | A. Wu | Weill Cornell Medicine (US) | — |
| 5 | A. Tellez | Weill Cornell Medicine (US) | — |
| 6 | H. Zou | Cornell University (US) | — |
| 7 | Pawan Kumar Singh | Weill Cornell Medicine (US) | |
| 8 | Kohta Saito | Weill Cornell Medicine (US) | |
| 9 | Saurabh Mishra | Weill Cornell Medicine (US) | |
| 10 | M. Brown | Weill Cornell Medicine (US) | — |
| 11 | A. Saleh | Weill Cornell Medicine (US) | — |
| 12 | Narineh M. Odjourian | Hackensack Meridian Health (US) | |
| 13 | Melissa Cristaldo | Hackensack Meridian Health (US) | — |
| 14 | M. Gan | University of North Carolina a… (US) | — |
| 15 | Q. Liu | University of North Carolina a… (US) | — |
| 16 | Martin Gengenbacher | Hackensack Meridian Health (US) Hackensack Meridian School of … (US) | |
| 17 | Seth Andrew Darst | Rockefeller University (US) | |
| 18 | Elizabeth A. Campbell | Rockefeller University (US) | |
| 19 | Carl Nathan | Weill Cornell Medicine (US) | |
| 20 | K. Y. Rhee Corresponding | Weill Cornell Medicine (US) | — |
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