CircRNA_103809/miR-516a/FBXL18 contributes to stemness and Gemcitabine Resistance of bladder cancer cells

Introduction: Bladder cancer is a highly recurrent malignancy and frequently shows drug resistance. Although gemcitabine initially works well for most patients, the majority of treated patients progressively generate resistance after multiple rounds of therapy, eventually leading to tumor recurrence. Recent studies suggest that a small subpopulation of cancer cells with stem cell-like properties -…