P-43. A Single Composite Peptide Vaccine Comprising Conserved Influenza Epitopes Formulated with ALFQ Adjuvant Induced Broadly Reactive Antibodies to Human, Avian, and Swine Influenza Viruses

Abstract Background Reassortant influenza strains containing genes from human, avian, and/or swine origin, have led to major outbreaks, such as the 2009 swine flu pandemic. The ongoing global spread of highly pathogenic avian influenza (HPAI) A/H5N1 virus among poultry highlights the risk of zoonotic transmission leading to pandemics. A universal influenza vaccine that generates broadly neutralizi…