Oxidative pathways of apo, partially, and fully Zn( II )‐ and Cd( II )‐metalated human metallothionein‐3 are dominated by disulfide bond formation

Oxidative stress is a key component of many diseases, including neurodegenerative diseases such as Alzheimer's disease. Reactive oxygen species (ROS) such as hydrogen peroxide and nitric oxide lead to disease progression by binding to proteins and causing their dysregulation. Metallothionein-3 (MT3), a cysteine-rich brain-located metalloprotein, has been proposed to be a key player in controlling…