Single cell multi-omics analysis of chronic myeloid leukemia…
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- DOI 10.7554/elife.92074.2
- OpenAlex ID W4393992282
- Type Preprint
- Language EN
- Published 05 Apr 2024
- Source eLife
- Publisher eLife Sciences Publications Ltd
- Countries 3
- Institutions 6
- Added 06 Apr 2024
- Updated 16 Oct 2026
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Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response
Preprint 2024 EN Gold
Abstract The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment. The sustained presence, heterogeneity and evolvability of LSCs are imperative for disease progression as well as recurrence during…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
11 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Rebecca Warfvinge | Lund University (SE) | — |
| 2 | Linda Geironson Ulfsson | Lund University (SE) | — |
| 3 | Parashar Dhapola | Lund University (SE) | |
| 4 | Fatemeh Safi | Lund University (SE) | |
| 5 | Mikael N.E. Sommarin | Lund University (SE) | |
| 6 | Shamit Soneji | Lund University (SE) | |
| 7 | Henrik Hjorth‐Hansen | Norwegian University of Scienc… (NO) St Olav's University Hospital (NO) | |
| 8 | Satu M. Mustjoki | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 9 | Johan Richter | Lund University (SE) Skåne University Hospital (SE) | |
| 10 | Ram Krishna Thakur | Lund University (SE) | — |
| 11 | Göran Karlsson | Lund University (SE) |
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