Author Response: Single cell multi-omics analysis of chronic…

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  • DOI 10.7554/elife.92074.2.sa3
  • OpenAlex ID W4393991502
  • Type Peer-review
  • Language EN
  • Published 05 Apr 2024
  • Source eLife
  • Publisher eLife Sciences Publications Ltd
  • Countries 3
  • Institutions 3
  • Added 06 Apr 2024
  • Updated 28 Oct 2026
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Author Response: Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

Peer-review 2024 EN Gold

The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment. The sustained presence, heterogeneity and evolvability of LSCs are imperative for disease progression as well as recurrence during treatmen…

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Keywords
UN Sustainable Development Goals
1 SDGs
Authors & Affiliations
11 authors
#AuthorInstitutionsORCID
1 Rebecca Warfvinge Lund University (SE) —
2 Linda Geironson Ulfsson Lund University (SE) —
3 Parashar Dhapola Lund University (SE)
4 Fatemeh Safi Lund University (SE)
5 Mikael N.E. Sommarin Lund University (SE)
6 Shamit Soneji Lund University (SE)
7 Henrik Hjorth‐Hansen St Olav's University Hospital (NO)
8 Satu M. Mustjoki University of Helsinki (FI)
9 Johan Richter Lund University (SE)
10 Ram Krishna Thakur Lund University (SE) —
11 Göran Karlsson Lund University (SE)

Data: OpenAlex