Treatment-free remission after a second TKI discontinuation …
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- DOI 10.1038/s41375-024-02145-6
- PMID https://pubmed.ncbi.nlm.nih.gov/38278960
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/10997502
- OpenAlex ID W4391262783
- Type Article
- Language EN
- Published 26 Jan 2024
- Volume 38 (4)
- Pages 781–787
- Source Leukemia
- Publisher Springer Nature
- FWCI 5.55
- Countries 8
- Institutions 26
- Added 27 Jan 2024
- Updated 28 Oct 2026
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Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib – interim results from the DAstop2 trial
Article 2024 EN Hybrid
Abstract Tyrosine kinase inhibitor (TKI) discontinuation in chronic myeloid leukemia (CML) has become part of routine care for patients with a sustained deep molecular response (DMR). Approximately 50% experience a molecular relapse upon TKI cessation. Most of them quickly regain DMR upon TKI resumption. Whether these patients can achieve a second treatment-free remission (TFR) remains unclear. DA…
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20 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Hjalmar Flygt Corresponding | Uppsala University Hospital (SE) | |
| 2 | Stina Söderlund | Uppsala University Hospital (SE) | — |
| 3 | Johan Richter | Skåne University Hospital (SE) | |
| 4 | Susanne Saußele | Heidelberg University (DE) Medizinische Fakultät Mannheim (DE) | |
| 5 | Perttu Koskenvesa | Helsinki University Hospital (FI) | |
| 6 | Leif Stenke | Karolinska University Hospital (SE) Karolinska Institutet (SE) | |
| 7 | Satu M. Mustjoki | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 8 | Andreja Dimitrijevic | Odense University Hospital (DK) | |
| 9 | Jesper Stentoft | Aarhus University Hospital (DK) | |
| 10 | Waleed M. Majeed | Stavanger University Hospital (NO) | |
| 11 | Lydia Roy | Université Paris-Est Créteil (FR) Assistance Publique – Hôpitaux… (FR) +2 | |
| 12 | Dominik Georg Friedrich Wolf | Innsbruck Medical University (AT) Universität Innsbruck (AT) +2 | |
| 13 | Arta Dreimane | Linköping University Hospital (SE) | — |
| 14 | Bjørn Tore Gjertsen | Haukeland University Hospital (NO) | |
| 15 | Tobias Gedde‐Dahl | Oslo University Hospital (NO) | |
| 16 | Erik Ahlstrand | Örebro University (SE) | |
| 17 | Berit Markevärn | University Hospital of Umeå (SE) | — |
| 18 | Henrik Hjorth‐Hansen | St Olav's University Hospital (NO) | |
| 19 | Jeroen J. W. M. Janssen | Radboud University Medical Cen… (NL) | |
| 20 | Ulla Olsson‐Strömberg | Uppsala University Hospital (SE) | — |
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