seco-1-Azacubane-2-carboxylic Acid: Derivative Scope and Com…

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2023
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  • DOI 10.1021/acs.joc.3c02333
  • PMID https://pubmed.ncbi.nlm.nih.gov/38131648
  • OpenAlex ID W4390114018
  • Type Article
  • Language EN
  • Published 22 Dec 2023
  • Volume 89 (1)
  • Pages 798–803
  • Source The Journal of Organic Chemistry
  • Publisher American Chemical Society
  • FWCI 0.09
  • Countries 1
  • Institutions 3
  • Added 23 Dec 2023
  • Updated 17 Oct 2026
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seco-1-Azacubane-2-carboxylic Acid: Derivative Scope and Comparative Biological Evaluation

Article 2023 EN

-1-azacubane-2-carboxylic acid, was incorporated into a range of bioactive chemical templates, including enalaprilat, perindoprilat, endomorphin-2 and isoniazid, and subjected to biological testing. The endomorphin-2 derivative displayed increased activity at the δ opioid receptor, but a loss in activity was observed in the other cases, although human normal cell line evaluation suggests limited c…

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0.09

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13 authors
#AuthorInstitutionsORCID
1 Dehui Kong The University of Queensland (AU)
2 Tyler Fahrenhorst‐Jones The University of Queensland (AU)
3 Andy Kuo The University of Queensland (AU)
4 Jacinta L. Simmons QIMR Berghofer Medical Researc… (AU)
5 Lendl Tan The University of Queensland (AU)
6 Jed M. Burns The University of Queensland (AU)
7 Gregory K. Pierens The University of Queensland (AU)
8 Rui Li The University of Queensland (AU) —
9 Nicholas P. West The University of Queensland (AU)
10 Glen M. Boyle QIMR Berghofer Medical Researc… (AU)
11 Maree Therese Smith The University of Queensland (AU)
12 G. Paul Savage CSIRO Manufacturing (AU)
13 Craig M. Williams Corresponding The University of Queensland (AU)
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