Evaluation of the efficacy and safety of amustaline/glutathi…

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Evaluation of the efficacy and safety of amustaline/glutathione pathogen-reduced RBCs in complex cardiac surgery: the Red Cell Pathogen Inactivation (ReCePI) study—protocol for a phase 3, randomized, controlled trial

Article 2023 EN Gold

BACKGROUND: Red blood cell (RBC) transfusion is a critical supportive therapy in cardiovascular surgery (CVS). Donor selection and testing have reduced the risk of transfusion-transmitted infections; however, risks remain from bacteria, emerging viruses, pathogens for which testing is not performed and from residual donor leukocytes. Amustaline (S-303)/glutathione (GSH) treatment pathogen reductio…

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30 authors
#AuthorInstitutionsORCID
1 Edward L. Snyder Yale University (US)
2 Michael E. Sekela University of Kentucky (US)
3 Ian J. Welsby Duke Medical Center (US)
4 Yoshiya Toyoda Temple University Hospital (US)
5 Mohamed S. Alsammak Temple University Health Syste… (US)
6 Neel Raj Sodha Rhode Island Hospital (US)
7 Thomas Mark Beaver University of Florida (US)
8 J. Peter R. Pelletier University of Florida (US)
9 James D. Gorham University of Virginia Health … (US)
10 John S. McNeil University of Virginia Health … (US)
11 Roman M. Sniecinski Emory University (US)
12 Ronald G. Pearl Stanford University (US)
13 Gregory A. Nuttall Mayo Clinic (US)
14 Ravi Sarode The University of Texas Southw… (US)
15 Thomas Brett Reece University of Colorado Hospita… (US)
16 Alesia Kaplan Vitalant (US) University of Pittsburgh Medic… (US)
17 Robertson D. Davenport University of Michigan (US) —
18 Tina S. Ipe Oklahoma Blood Institute (US) University of Arkansas for Med… (US)
19 Peyman Benharash University of California, Los … (US)
20 Ileana Lopez‐Plaza Henry Ford Hospital (US) —
21 Richard R. Gammon OneBlood (US)
22 Patrick Sadler — —
23 John P. Pitman Cerus (United States) (US)
24 Kathy Liu Cerus (United States) (US) —
25 Stanley Bentow Cerus (United States) (US) —
26 Laurence Corash Cerus (United States) (US)
27 Nina Mufti Cerus (United States) (US) —
28 Jeanne Varrone Cerus (United States) (US) —
29 Richard J. Benjamin Corresponding Cerus (United States) (US)
30 for the ReCePI study group — —

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