Single-cell multiomics analysis of chronic myeloid leukemia …
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- DOI 10.7554/elife.92074
- PMID https://pubmed.ncbi.nlm.nih.gov/39503729
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/11540304
- OpenAlex ID W4389177374
- Type Preprint
- Language EN
- Published 30 Nov 2023
- Volume 12
- Source eLife
- Publisher eLife Sciences Publications Ltd
- Countries 3
- Institutions 6
- Added 01 Dec 2023
- Updated 31 Oct 2026
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Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response
Preprint 2023 EN Gold
The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment and are imperative for disease progression as well as recurrence during treatment-free remission (TFR). Here, we have generated high-resolut…
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11 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Rebecca Warfvinge | Lund University (SE) | — |
| 2 | Linda Geironson Ulfsson | Lund University (SE) | — |
| 3 | Parashar Dhapola | Lund University (SE) | |
| 4 | Fatemeh Safi | Lund University (SE) | |
| 5 | Mikael N.E. Sommarin | Lund University (SE) | |
| 6 | Shamit Soneji | Lund University (SE) | |
| 7 | Henrik Hjorth‐Hansen | Norwegian University of Scienc… (NO) St Olav's University Hospital (NO) | |
| 8 | Satu M. Mustjoki | University of Helsinki (FI) Helsinki University Hospital (FI) | |
| 9 | Johan Richter | Lund University (SE) Skåne University Hospital (SE) | |
| 10 | Ram Krishna Thakur Corresponding | Lund University (SE) | — |
| 11 | Göran Karlsson Corresponding | Lund University (SE) |
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