Stretch-Induced Down-Regulation of HCN2 Suppresses Contracti…

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Stretch-Induced Down-Regulation of HCN2 Suppresses Contractile Activity

Article 2023 EN Gold

Although hyperpolarization-activated and cyclic nucleotide-gated 2 channels (HCN2) are expressed in multiple cell types in the gut, the role of HCN2 in intestinal motility is poorly understood. HCN2 is down-regulated in intestinal smooth muscle in a rodent model of ileus. Thus, the purpose of this study was to determine the effects of HCN inhibition on intestinal motility. HCN inhibition with ZD72…

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UN Sustainable Development Goals
1 SDGs
Authors & Affiliations
10 authors
#AuthorInstitutionsORCID
1 Job Baffin Kola University of Debrecen (HU) —
2 Botagoz Turarova University of Debrecen (HU)
3 Dóra Csige University of Debrecen (HU)
4 Ádám Sipos University of Debrecen (HU) —
5 Luca Varga University of Debrecen (HU) —
6 Bence Gergely University of Debrecen (HU)
7 Farah Al Refai University of Debrecen (HU)
8 Iván P. Uray University of Debrecen (HU)
9 Tibor Docsa University of Debrecen (HU) —
10 Karen Uray Corresponding University of Debrecen (HU)

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