R68070, a combined thromboxane/endoperoxide receptor antagon…
Established
47
Citations29
Refs1990
Year
Search Works
Work Details
- DOI 10.1182/blood.v75.3.646.646
- PMID https://pubmed.ncbi.nlm.nih.gov/2153424
- OpenAlex ID W149875176
- Type Article
- Language EN
- Published 01 Feb 1990
- Volume 75 (3)
- Pages 646–653
- Source Blood
- Publisher Elsevier BV
- FWCI 4.00
- Countries 1
- Institutions 1
- Added 10 Oct 2025
- Updated 12 Oct 2026
External Links
MENU
0
R68070, a combined thromboxane/endoperoxide receptor antagonist and thromboxane synthase inhibitor, inhibits human platelet activation in vitro and in vivo: a comparison with aspirin
Article 1990 EN Bronze
We have investigated the effects of R68070 on platelet function in vitro and in vivo. The drug inhibits U46619-induced aggregation (IC50 = 1.2 x 10(-6) mol/L), blocks serum thromboxane formation (IC50 = 1 x 10(-7) mol/L), and increases serum prostaglandin (PG)E2 and 6-keto-PGF1 alpha levels, indicating that it combines thromboxane receptor blocking and thromboxane synthase inhibiting properties. T…
47
Citations
29
References
6
Authors
4.00
FWCI
Topics
Keywords
UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
6 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Bernard Hoet | KU Leuven (BE) | |
| 2 | C Falcón | KU Leuven (BE) | — |
| 3 | Stef De Reys | KU Leuven (BE) | — |
| 4 | Jef Arnout | KU Leuven (BE) | — |
| 5 | Hans Deckmyn | KU Leuven (BE) | |
| 6 | J. Vermylen | KU Leuven (BE) | — |
Related Works
10Data: OpenAlex