Compassionate Use of Avacopan in Difficult-to-Treat Antineut…

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Compassionate Use of Avacopan in Difficult-to-Treat Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Article 2021 EN Gold

Avacopan is a new, promising treatment for antineutrophil cytoplasmic antibody–associated vasculitis (AAV) and can potentially, significantly reduce steroid use. There were 2 phase 2 trials1,2 and 1 phase 3 trial3 which concluded that avacopan was safe with no higher incidence of adverse events in patients with AAV. Compared with steroids added to standard immunosuppression with cyclophosphamide o…

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12

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12 authors
#AuthorInstitutionsORCID
1 Jolijn R. van Leeuwen Leiden University (NL) Leiden University Medical Cent… (NL)
2 Obbo W Bredewold Leiden University (NL) Leiden University Medical Cent… (NL)
3 Laura S. van Dam Leiden University (NL) Leiden University Medical Cent… (NL)
4 Stella L. Werkman Leiden University (NL) Leiden University Medical Cent… (NL) —
5 Jacqueline T. Jonker Leiden University (NL) Leiden University Medical Cent… (NL) +1
6 Miranda Geelhoed Leiden University (NL) Leiden University Medical Cent… (NL) —
7 Antonius P. M. Langeveld Leiden University (NL) Leiden University Medical Cent… (NL) —
8 Hilde H.F. Remmelts Meander Medisch Centrum (NL)
9 Maud M. van den Broecke Leiden University (NL) Leiden University Medical Cent… (NL) —
10 Argho Ray Leiden University (NL) Leiden University Medical Cent… (NL) —
11 Ton J. Rabelink Leiden University (NL) Leiden University Medical Cent… (NL)
12 Y K Onno Teng Corresponding Leiden University (NL) Leiden University Medical Cent… (NL)

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