Gasdermin D mediates host cell death but not interleukin-1β …
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- DOI 10.1038/s41420-021-00716-5
- PMID https://pubmed.ncbi.nlm.nih.gov/34718331
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/8557205
- OpenAlex ID W3211276254
- Type Article
- Language EN
- Published 30 Oct 2021
- Volume 7 (1)
- Pages 327
- Source Cell Death Discovery
- Publisher Springer Nature
- FWCI 0.79
- Countries 1
- Institutions 4
- Added 08 Nov 2021
- Updated 28 Oct 2026
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Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages
Article 2021 EN Gold
Necrotic cell death represents a major pathogenic mechanism of Mycobacterium tuberculosis (Mtb) infection. It is increasingly evident that Mtb induces several types of regulated necrosis but how these are interconnected and linked to the release of pro-inflammatory cytokines remains unknown. Exploiting a clinical cohort of tuberculosis patients, we show here that the number and size of necrotic le…
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11
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11 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Sebastian Julian Theobald | University of Cologne (DE) | — |
| 2 | Jessica Gräb | University of Cologne (DE) | — |
| 3 | Melanie Fritsch | University of Cologne (DE) Cologne Excellence Cluster on … (DE) | |
| 4 | Isabelle Suárez | University of Cologne (DE) German Center for Infection Re… (DE) | |
| 5 | Hannah S. Eisfeld | University of Cologne (DE) | — |
| 6 | Sandra Winter | University of Cologne (DE) | — |
| 7 | Maximilian Koch | University of Cologne (DE) Cologne Excellence Cluster on … (DE) | — |
| 8 | Christoph Hölscher | German Center for Infection Re… (DE) Research Center Borstel - Leib… (DE) | |
| 9 | Manolis Pasparakis | University of Cologne (DE) Cologne Excellence Cluster on … (DE) | |
| 10 | Hamid Kashkar | University of Cologne (DE) Cologne Excellence Cluster on … (DE) | |
| 11 | Jan Rybniker Corresponding | University of Cologne (DE) German Center for Infection Re… (DE) |
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