Tau and Membranes: Interactions That Promote Folding and Con…

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Tau and Membranes: Interactions That Promote Folding and Condensation

Article 2021 EN Gold

Tau misfolding and assembly is linked to a number of neurodegenerative diseases collectively described as tauopathies, including Alzheimer's disease (AD) and Parkinson's disease. Anionic cellular membranes, such as the cytosolic leaflet of the plasma membrane, are sites that concentrate and neutralize tau, primarily due to electrostatic interactions with tau's microtubule binding repeat domain (RD…

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7 authors
#AuthorInstitutionsORCID
1 Chad A. Sallaberry University of Colorado Colorad… (US) —
2 Barbie J. Voss University of Colorado Colorad… (US) —
3 Jaroslaw P. Majewski U.S. National Science Foundati… (US) Los Alamos National Laboratory (US) +2
4 Jacek Biernat German Center for Neurodegener… (DE)
5 Eckhard Mandelkow� University of Bonn (DE) Center of Advanced European St… (DE) +1
6 Eva Y. Chi University of New Mexico (US)
7 Crystal M. Vander Zanden Corresponding University of Colorado Colorad… (US)

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