Deletion of Mocos Induces Xanthinuria with Obstructive Nephr…
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Refs2021
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- DOI 10.34067/kid.0001732021
- PMID https://pubmed.ncbi.nlm.nih.gov/35372998
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/8785848
- OpenAlex ID W3199621507
- Type Article
- Language EN
- Published 17 Sep 2021
- Volume 2 (11)
- Pages 1793–1806
- Source Kidney360
- Publisher Lippincott Williams & Wilkins
- FWCI 0.24
- Countries 2
- Institutions 10
- Added 27 Sep 2021
- Updated 28 Oct 2026
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Deletion of Mocos Induces Xanthinuria with Obstructive Nephropathy and Major Metabolic Disorders in Mice
Article 2021 EN Diamond
Key Points A knockout mouse targeting the molybdenum cofactor sulfurase ( Mocos ) gene develops xanthinuria type II with lethal obstructive nephropathy. Xanthinuric Mocos knockout mice display moderate renal inflammation and fibrosis, normocytic anemia, and reduced detoxification defense systems. Purine, but also amino acid and phospholipid, metabolic pathways are altered in Mocos knockout kidneys…
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16
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0.24
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
16 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Delphine Sedda | Université d'Orléans (FR) Centre National de la Recherch… (FR) +1 | |
| 2 | Claire Mackowiak | Université d'Orléans (FR) Centre National de la Recherch… (FR) +1 | |
| 3 | Julie Pailloux | Université d'Orléans (FR) Centre National de la Recherch… (FR) +1 | — |
| 4 | Elodie Culerier | Université d'Orléans (FR) Centre National de la Recherch… (FR) +1 | — |
| 5 | Ana Dudas | Université d'Orléans (FR) Centre National de la Recherch… (FR) +1 | |
| 6 | Pauline Rontani | Centre National de la Recherch… (FR) Aix-Marseille Université (FR) +1 | — |
| 7 | Nicolas Erard Corresponding | Centre National de la Recherch… (FR) Aix-Marseille Université (FR) +1 | — |
| 8 | Antoine Lefevre | Université de Tours (FR) Inserm (FR) +1 | — |
| 9 | Sylvie Mavel | Université de Tours (FR) Inserm (FR) +1 | |
| 10 | Patrick Emond | Université de Tours (FR) Inserm (FR) +1 | |
| 11 | Frédéric Foucher | Centre National de la Recherch… (FR) Centre de Biophysique Molécula… (FR) | |
| 12 | Marc Le Bert | Université d'Orléans (FR) Centre National de la Recherch… (FR) +1 | |
| 13 | Valerie F. J. Quesniaux | Université d'Orléans (FR) Centre National de la Recherch… (FR) +1 | |
| 14 | Michael J. Mihatsch | University Hospital of Basel (CH) | — |
| 15 | Bernhard Ryffel | Université d'Orléans (FR) Centre National de la Recherch… (FR) +1 | |
| 16 | Madeleine Garcia Corresponding | Université d'Orléans (FR) Centre National de la Recherch… (FR) +1 |
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