Pharmacodynamic Evaluation of a Single Dose versus a 24-Hour…
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- DOI 10.3390/antibiotics10050602
- PMID https://pubmed.ncbi.nlm.nih.gov/34069492
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/8161008
- OpenAlex ID W3160831150
- Type Article
- Language EN
- Published 19 May 2021
- Volume 10 (5)
- Pages 602
- Source Antibiotics
- Publisher Multidisciplinary Digital Publishin…
- FWCI 0.29
- Countries 2
- Institutions 5
- Added 24 May 2021
- Updated 28 Oct 2026
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Pharmacodynamic Evaluation of a Single Dose versus a 24-Hour Course of Multiple Doses of Cefazolin for Surgical Prophylaxis
Article 2021 EN Gold
The optimal perioperative duration for the administration of cefazolin and other prophylactic antibiotics remains unclear. This study aimed to describe the pharmacodynamics of cefazolin for a single 2 g dose versus a 24 h course of a 2 g single dose plus a 1 g eight-hourly regimen against methicillin-susceptible Staphylococcus aureus. Static concentration time–kill assay and a dynamic in vitro hol…
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7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Aaron James Heffernan | Griffith University (AU) The University of Queensland (AU) | |
| 2 | Jowana Alawie | The University of Queensland (AU) | — |
| 3 | Steven C. Wallis | The University of Queensland (AU) | |
| 4 | Saiyuri Naicker | The University of Queensland (AU) | |
| 5 | Santosh Kumar Sreevatsav Adiraju | The University of Queensland (AU) | |
| 6 | Jason Alexander Roberts | The University of Queensland (AU) Université de Montpellier (FR) +2 | |
| 7 | Fekade Bruck Sime Corresponding | The University of Queensland (AU) |
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