Study Protocol for a Pilot, Open-Label, Prospective, and Obs…
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- DOI 10.3390/mps2020038
- PMID https://pubmed.ncbi.nlm.nih.gov/31164617
- OpenAlex ID W2945820649
- Type Article
- Language EN
- Published 13 May 2019
- Volume 2 (2)
- Pages 38
- Source Methods and Protocols
- Publisher Multidisciplinary Digital Publishin…
- Countries 1
- Institutions 2
- Added 10 Oct 2025
- Updated 17 Oct 2026
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Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy
Article 2019 EN Gold
Pharmacokinetic alterations of medications administered during surgeries involving cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) have been reported. The impact of CPB on the cytochrome P450 (CYP) enzymes' activity is the key factor. The metabolic rates of caffeine, dextromethorphan, midazolam, omeprazole, and Losartan to the CYP-specific metabolites are validated meas…
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1 SDGsAuthors & Affiliations
9 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Santosh Kumar Sreevatsav Adiraju Corresponding | The University of Queensland (AU) | |
| 2 | Kiran Shekar | Prince Charles Hospital (AU) | |
| 3 | Peter J. Tesar | Prince Charles Hospital (AU) | — |
| 4 | Rishendran Naidoo | Prince Charles Hospital (AU) | — |
| 5 | Ivan L. Rapchuk | Prince Charles Hospital (AU) | |
| 6 | Stephen Belz | Prince Charles Hospital (AU) | — |
| 7 | John Francis Fraser | Prince Charles Hospital (AU) | |
| 8 | Maree Therese Smith | The University of Queensland (AU) | |
| 9 | Sussan Ghassabian | The University of Queensland (AU) |
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