Diagnosis and management of von Willebrand disease in Australia

Abstract: Von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder, and can also arise as an acquired event where it is termed von Willebrand syndrome. Both arise from deficiency and/or defect of von Willebrand factor (VWF), an adhesive plasma protein that acts primarily to prevent bleeding by anchoring platelets to sites of vascular injury. Factor VIII is also propor…