Establishment of Immunodeficient Retinal Degeneration Model …

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2018
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Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation

Article 2018 EN Gold

Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies. Here, we established two mouse models of end-stage retinal degeneration with immunodeficiency, NOG-rd1-2J and NOG-rd10, and characterized disease progress and immunodeficient status. We also transplanted human ESC-derived retinal sheets into NOG…

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UN Sustainable Development Goals
1 SDGs
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19 authors
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1 Satoshi Iraha Kyoto University (JP) RIKEN (JP) +1
2 Hung‐Ya Tu RIKEN (JP)
3 Suguru Yamasaki Sumitomo Dainippon Pharma (Jap… (JP) RIKEN (JP)
4 Takahiro Kagawa Central Institute for Experime… (JP) —
5 Motohito Goto Central Institute for Experime… (JP)
6 Riichi Takahashi Central Institute for Experime… (JP)
7 Takehito Watanabe RIKEN (JP) —
8 Sunao Sugita RIKEN (JP)
9 Shigenobu Yonemura RIKEN (JP) Tokushima University (JP)
10 Genshiro A. Sunagawa RIKEN (JP)
11 Take Matsuyama RIKEN (JP)
12 Momo Fujii RIKEN (JP)
13 Atsushi Kuwahara Sumitomo Dainippon Pharma (Jap… (JP)
14 Akiyoshi Kishino Sumitomo Dainippon Pharma (Jap… (JP) —
15 Naoshi Koide RIKEN (JP) —
16 Mototsugu Eiraku RIKEN (JP)
17 Hidenobu Tanihara Kumamoto University (JP)
18 Masayo Takahashi Kyoto University (JP) RIKEN (JP)
19 Michiko Mandai Corresponding RIKEN (JP)
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