Dysregulation of the miR-146a-Smad4 axis impairs osteogenesi…
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- DOI 10.1038/boneres.2017.37
- PMID https://pubmed.ncbi.nlm.nih.gov/29167750
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/5698258
- OpenAlex ID W2770992939
- Type Article
- Language EN
- Published 21 Nov 2017
- Volume 5 (1)
- Pages 17037
- Source Bone Research
- Publisher Springer Nature
- FWCI 1.56
- Countries 1
- Institutions 5
- Added 04 Dec 2017
- Updated 28 Oct 2026
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Dysregulation of the miR-146a-Smad4 axis impairs osteogenesis of bone mesenchymal stem cells under inflammation
Article 2017 EN Gold
Abstract Osteoporosis is a common disease that affects patient quality of life, especially among the elderly population. Although inflammation contributes significantly to osteoporosis, the underlying mechanism is unclear. In this study, we found that tumor necrosis factor (TNF)-α, an inflammatory environment mimic, inhibits osteogenesis of bone mesenchymal stem cells (BMSCs), induces miR-146a and…
48
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27
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7
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1.56
FWCI
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1 SDGsAuthors & Affiliations
7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Wei Kuang | General Hospital of Guangzhou … (CN) | |
| 2 | Liwei Zheng | Sichuan University (CN) State Key Laboratory of Oral D… (CN) | |
| 3 | Xin Xu | Sichuan University (CN) State Key Laboratory of Oral D… (CN) | |
| 4 | Yao Lin | Sun Yat-sen University (CN) Hospital of Stomatology, Sun Y… (CN) | |
| 5 | Jiong Lin | Sun Yat-sen University (CN) Hospital of Stomatology, Sun Y… (CN) | |
| 6 | Jiahua Wu | Sun Yat-sen University (CN) Hospital of Stomatology, Sun Y… (CN) | |
| 7 | Jiali Tan Corresponding | Sun Yat-sen University (CN) Hospital of Stomatology, Sun Y… (CN) |
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