Prospective Analysis in GIST Patients on the Role of Alpha-1…
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- DOI 10.1007/s40262-016-0441-0
- PMID https://pubmed.ncbi.nlm.nih.gov/27461250
- OpenAlex ID W2495506207
- Type Article
- Language EN
- Published 26 Jul 2016
- Volume 56 (3)
- Pages 305–310
- Source Clinical Pharmacokinetics
- Publisher Adis, Springer Healthcare
- FWCI 0.92
- Countries 1
- Institutions 1
- Added 10 Oct 2025
- Updated 16 Oct 2026
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Prospective Analysis in GIST Patients on the Role of Alpha-1 Acid Glycoprotein in Imatinib Exposure
Article 2016 EN Hybrid
For imatinib, a relationship between systemic exposure and clinical outcome has been suggested. Importantly, imatinib concentrations are not stable and decrease over time, for which several mechanisms have been suggested. In this study, we investigated if a decrease in alpha-1 acid glycoprotein (AGP) is the main cause of the lowering in imatinib exposure over time. We prospectively measured imatin…
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1 SDGsAuthors & Affiliations
8 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Sander Bins | Erasmus MC Cancer Institute (NL) | |
| 2 | Karel Eechoute | Erasmus MC Cancer Institute (NL) | |
| 3 | Jacqueline S. L. Kloth | Erasmus MC Cancer Institute (NL) | — |
| 4 | Femke M. de Man | Erasmus MC Cancer Institute (NL) | |
| 5 | Astrid W. Oosten | Erasmus MC Cancer Institute (NL) | |
| 6 | Peter de Bruijn | Erasmus MC Cancer Institute (NL) | |
| 7 | Stefan Sleijfer | Erasmus MC Cancer Institute (NL) | |
| 8 | Ron H.J. Mathijssen Corresponding | Erasmus MC Cancer Institute (NL) |
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