Mechanobiology of Bone Tissue and Bone Cells

Bone remodeling is the continuous turnover of bone matrix and mineral by bone resorption (activity of osteoclasts) and formation (activity of osteoblasts) in the adult skeleton. The mechanical environment plays an essential role in the regulation of bone remodeling in intact bone and of modeling during bone repair. Reduced loading during long-term immobilization or microgravity can result in signi…