A thorough QT/QTc study of multiple doses of tapentadol imme…

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  • DOI 10.5414/cpp48678
  • PMID https://pubmed.ncbi.nlm.nih.gov/20875374
  • OpenAlex ID W2330186663
  • Type Article
  • Language EN
  • Published 01 Oct 2010
  • Volume 48 (10)
  • Pages 678–687
  • Source International Journal of Clinical Pharma…
  • Publisher Dustri-Verlag
  • FWCI 1.84
  • Countries 1
  • Institutions 1
  • Added 10 Oct 2025
  • Updated 02 Oct 2026
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A thorough QT/QTc study of multiple doses of tapentadol immediate release in healthy subjects

Article 2010 EN

OBJECTIVE: This randomized, double-blind, placebo- and positive-controlled 4-way crossover study evaluated the effects of tapentadol immediate release (IR) on the QT/QTc interval. MATERIALS AND METHODS: Healthy subjects received tapentadol IR 100 mg or 150 mg, or placebo, every 6 h on Days 1 and 2, with a >= 7-day washout between treatments. Moxifloxacin 400 mg was the positive control. Serial tri…

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8

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1.84

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1 SDGs
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8 authors
#AuthorInstitutionsORCID
1 Charles Oh Janssen Research & Development… (US)
2 Jens Rengelshausen —
3 B Mangold — —
4 Mila S. Etropolski — —
5 Christine Rauschkolb — —
6 S S Wang — —
7 David H. Upmalis — —
8 Thomas Häufel — —

Data: OpenAlex