Abstract 525: The Role of FHL2 in Mechanically Regulated Val…

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  • DOI 10.1161/atvb.34.suppl_1.525
  • OpenAlex ID W2256067614
  • Type Conference-abstract
  • Language EN
  • Published 01 May 2014
  • Volume 34 (suppl_1)
  • Source Arteriosclerosis Thrombosis and Vascular…
  • Publisher Lippincott Williams & Wilkins
  • Countries 1
  • Institutions 1
  • Added 24 Jun 2016
  • Updated 21 Aug 2026
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Abstract 525: The Role of FHL2 in Mechanically Regulated Valve Interstitial Cell Osteogenic Differentiation

Conference-abstract 2014 EN

Introduction: Lesions in calcific aortic valve disease (CAVD) often include osteoblasts and occur preferentially in the natively stiffer fibrosa side of the valve, suggesting roles for osteogenesis and matrix stiffness in CAVD. Valve interstitial cells (VICs) have osteogenic potential that is modulated by matrix stiffness in vitro . Osteogenesis of mesenchymal stem cells is mediated by FHL2 and mo…

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UN Sustainable Development Goals
1 SDGs
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3 authors
#AuthorInstitutionsORCID
1 Alan Y.L. Lam University of Toronto (CA) —
2 Jan‐Hung Chen University of Toronto (CA) —
3 Craig A. Simmons University of Toronto (CA)
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