Role of receptor occupancy assays by flow cytometry in drug …

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  • DOI 10.1002/cyto.b.21355
  • PMID https://pubmed.ncbi.nlm.nih.gov/26704557
  • OpenAlex ID W2220680479
  • Type Review
  • Language EN
  • Published 24 Dec 2015
  • Volume 90 (2)
  • Pages 110–116
  • Source Cytometry Part B Clinical Cytometry
  • Publisher Wiley
  • FWCI 0.42
  • Countries 3
  • Institutions 8
  • Added 24 Jun 2016
  • Updated 27 Oct 2026
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Role of receptor occupancy assays by flow cytometry in drug development

Review 2015 EN Hybrid

The measurement of the binding of a biotherapeutic to its cellular target, receptor occupancy (RO), is increasingly important in development of biologically-based therapeutic agents. Receptor occupancy (RO) assays by flow cytometry describe the qualitative and/or quantitative assessment of the binding of a therapeutic agent to its cell surface target. Such RO assays can be as simple as measuring t…

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0.42

FWCI

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16 authors
#AuthorInstitutionsORCID
1 Jennifer J. Stewart — —
2 Cherie L. Green Amgen (United States) (US) —
3 Nicholas Jones LabCorp (United States) (US) —
4 Meina Liang Mountain Vista Medical Center (US)
5 Yuanxin Xu Alnylam Pharmaceuticals (Unite… (US)
6 Danice E. C. Wilkins Charles River Laboratories (Un… (US) —
7 Maxime Moulard —
8 Kamila Czechowska European Organization for Nucl… (CH)
9 David Lanham Eurofins (United Kingdom) (GB)
10 Thomas W. McCloskey — —
11 John Ferbas Amgen (United States) (US)
12 Barry W. A. van der Strate — —
13 Carl‐Magnus Högerkorp — —
14 Timothy L. Wyant —
15 Alan Lackey LabCorp (United States) (US)
16 Virginia Litwin Corresponding Covance (United States) (US)
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