Effect of Estrogen versus Testosterone on Circulating Osteop…

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2002
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  • DOI 10.1210/jc.87.4.1550
  • PMID https://pubmed.ncbi.nlm.nih.gov/11932280
  • OpenAlex ID W2124998345
  • Type Article
  • Language EN
  • Published 01 Apr 2002
  • Volume 87 (4)
  • Pages 1550–1554
  • Source The Journal of Clinical Endocrinology & …
  • Publisher Oxford University Press
  • FWCI 6.80
  • Countries 1
  • Institutions 2
  • Added 24 Jun 2016
  • Updated 16 Oct 2026
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Effect of Estrogen versus Testosterone on Circulating Osteoprotegerin and Other Cytokine Levels in Normal Elderly Men

Article 2002 EN

Recent studies have shown that estrogen (E) likely plays a dominant role in inhibiting bone resorption in normal elderly men. Because both E and T inhibit osteoclast development and activity, stimulate osteoclast apoptosis, and inhibit osteoblast production of IL-6, it is unclear why T is less potent than E in inhibiting bone resorption in vivo. Osteoprotegerin (OPG) binds to and inactivates RANKL…

191

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32

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4

Authors

6.80

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4 authors
#AuthorInstitutionsORCID
1 Sundeep Khosla Corresponding Mayo Clinic (US)
2 Elizabeth J. Atkinson Mayo Clinic (US)
3 Colin Robert Dunstan Amgen (United States) (US)
4 W. Michael O’Fallon Mayo Clinic (US) —

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