Neurophysiological and neurochemical alterations during electrical stimulation of human caudate nucleus

Lumbar cerebrospinal fluid (CSF) norepinephrine (NE) concentrations were preoperatively determined in five patients using a radioenzymatic assay technique. Stereotaxic thalamotomy was performed using depth coagulating electrodes with stimulating points at 5.0-mm intervals along the shaft. No significant alterations in prestimulation lumbar CSF NE levels were noted 12 days after electrode installat…