The Oncogenic EWS-FLI1 Protein Binds In Vivo GGAA Microsatel…

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The Oncogenic EWS-FLI1 Protein Binds In Vivo GGAA Microsatellite Sequences with Potential Transcriptional Activation Function

Article 2009 EN Gold

The fusion between EWS and ETS family members is a key oncogenic event in Ewing tumors and important EWS-FLI1 target genes have been identified. However, until now, the search for EWS-FLI1 targets has been limited to promoter regions and no genome-wide comprehensive analysis of in vivo EWS-FLI1 binding sites has been undertaken. Using a ChIP-Seq approach to investigate EWS-FLI1-bound DNA sequences…

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1 Noëlle Guillon Inserm (FR) Institut Curie (FR) —
2 Franck Tirode Inserm (FR) Institut Curie (FR)
3 Valentina Boeva Inserm (FR) Cancer et génome: Bioinformati… +1
4 Andrei Zynovyev Inserm (FR) Cancer et génome: Bioinformati… +1 —
5 Emmanuel Barillot Inserm (FR) Cancer et génome: Bioinformati… +1
6 Olivier Delattre Corresponding Inserm (FR) Institut Curie (FR)

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