Participation of tumor necrosis factor in the mediation of g…
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- DOI 10.1172/jci113540
- PMID https://pubmed.ncbi.nlm.nih.gov/3384955
- OpenAlex ID W2107907376
- Type Article
- Language EN
- Published 01 Jun 1988
- Volume 81 (6)
- Pages 1925–1937
- Source Journal of Clinical Investigation
- Publisher American Society for Clinical Inves…
- FWCI 45.52
- Countries 1
- Institutions 2
- Added 10 Oct 2025
- Updated 16 Oct 2026
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Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.
Article 1988 EN Bronze
Macrophages are induced by LPS to release a number of products that determine the host response during gram negative sepsis. To examine the role of one such substance, tumor necrosis factor (TNF), in mediating LPS-induced injury, we employed a rabbit model of endotoxic shock to (a) determine the kinetics and extent of release of TNF into plasma after injection of LPS, and (b) to evaluate the prote…
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1 SDGsAuthors & Affiliations
3 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | John C. Mathison | Scripps Research Institute (US) Scripps Clinic (US) | — |
| 2 | Eliza B. Wolfson | Scripps Clinic (US) | — |
| 3 | Richard J. Ulevitch | Scripps Clinic (US) |
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