Diabetes Impairs Hypothalamo-Pituitary-Adrenal (HPA) Respons…
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- DOI 10.2337/diabetes.51.6.1681
- PMID https://pubmed.ncbi.nlm.nih.gov/12031953
- OpenAlex ID W2105295482
- Type Article
- Language EN
- Published 01 Jun 2002
- Volume 51 (6)
- Pages 1681–1689
- Source Diabetes
- Publisher American Diabetes Association
- FWCI 2.07
- Countries 1
- Institutions 1
- Added 10 Oct 2025
- Updated 14 Oct 2026
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Diabetes Impairs Hypothalamo-Pituitary-Adrenal (HPA) Responses to Hypoglycemia, and Insulin Treatment Normalizes HPA but not Epinephrine Responses
Article 2002 EN
We recently established that in addition to plasma adrenocorticotrophic hormone (ACTH) and corticosterone, hypothalamic corticotrophin-releasing hormone (CRH) mRNA and hippocampal type 1 glucocorticoid receptor (GR1) mRNA were also upregulated in uncontrolled streptozotocin-induced diabetes. In the current study, control, diabetic, and insulin-treated diabetic rats underwent a hyperinsulinemic-hyp…
89
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53
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6
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2.07
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6 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Owen T. M. Chan | University of Toronto (CA) | |
| 2 | Stephen Chan | University of Toronto (CA) | — |
| 3 | Karen Inouye | University of Toronto (CA) | |
| 4 | Kathy Kar‐man Shum | University of Toronto (CA) | |
| 5 | Stephen G. Matthews | University of Toronto (CA) | |
| 6 | Mladen Vranić | University of Toronto (CA) | — |
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