Pressor effects of circulating endothelin are limited by its…

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Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

Article 1988 EN Green

Endothelin releases prostacyclin and thromboxane A2 from guinea pig or rat isolated lungs and endothelium-derived relaxing factor in the perfused mesentery of the rat. Endothelin is also substantially removed by the pulmonary circulation of the rat in vitro and in vivo and by guinea pig lungs in vitro. In the rat, the effects of endothelin on the blood pressure vary from pressor (in pithed rats) t…

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7 authors
#AuthorInstitutionsORCID
1 Gilberto De Nucci St Bartholomew's Hospital (GB) Queen Mary University of Londo… (GB) +1
2 R Thomas St Bartholomew's Hospital (GB) Queen Mary University of Londo… (GB) +1 —
3 Pedro D’Orléans-Juste St Bartholomew's Hospital (GB) Queen Mary University of Londo… (GB) +1
4 Edson Antunes St Bartholomew's Hospital (GB) Queen Mary University of Londo… (GB) +1
5 Claire E. Walder St Bartholomew's Hospital (GB) Queen Mary University of Londo… (GB) +1 —
6 Timothy David Warner St Bartholomew's Hospital (GB) Queen Mary University of Londo… (GB) +1
7 John Robert Vane St Bartholomew's Hospital (GB) Queen Mary University of Londo… (GB) +1 —

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