Hyperinsulinism in Dogs with Neoplasia of the Pancreatic Islets. A Clinical, Pathologic, and Ultrastructural Study

Neoplasms of the pancreatic islets in 6 of 9 dogs were functionally active and were associated with a syndrome of hyperinsulinism. The serum concentration of immunoreactive insulin in a dog with beta-cell carcinoma was increased compared to normal dogs. Metastases in the liver and lymph nodes remained functionally active and were responsive to tolbutamide following excision of the primary neoplasm…