Regulation of Monocyte Chemoattractant Protein-1 Gene Expression and Secretion in Rat Pulmonary Alveolar Macrophages by Lipopolysaccharide, Tumor Necrosis Factor-α, and Interleukin-1 β

Chemotactic cytokines coordinate the recruitment of leukocytes into the lung during pulmonary inflammation. In a previous study, we determined that rat pulmonary alveolar macrophages (PAMs) facilitate monocyte recruitment and activation in the lung during acute inflammatory lung injury, in part, through the inducible expression of monocyte chemoattractant protein-1 (MCP-1). MCP-1 is an 11 to 15 kD…