Analgesic and anti-inflammatory effects of A-286501, a novel…
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- DOI 10.1016/s0304-3959(01)00435-3
- PMID https://pubmed.ncbi.nlm.nih.gov/11932067
- OpenAlex ID W2063110821
- Type Article
- Language EN
- Published 01 Mar 2002
- Volume 96 (1)
- Pages 107–118
- Source Pain
- Publisher Lippincott Williams & Wilkins
- FWCI 2.58
- Countries 1
- Institutions 1
- Added 24 Jun 2016
- Updated 16 Oct 2026
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Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor
Article 2002 EN
Adenosine (ADO) is an inhibitory neuromodulator that can increase nociceptive thresholds in response to noxious stimulation. Inhibition of the ADO-metabolizing enzyme, adenosine kinase (AK) increases extracellular ADO concentrations at sites of tissue trauma and AK inhibitors may have therapeutic potential as analgesic and anti-inflammatory agents. N7-((1'R,2'S,3'R,4'S)-2',3'-dihydroxy-4'-amino-cy…
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14
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2.58
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
14 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Michael F. Jarvis Corresponding | Abbott (United States) (US) | |
| 2 | Haixia Yu | Abbott (United States) (US) | — |
| 3 | Steve McGaraughty | Abbott (United States) (US) | — |
| 4 | Carol T. Wismer | Abbott (United States) (US) | — |
| 5 | Joe P. Mikusa | Abbott (United States) (US) | — |
| 6 | Chang Zhu | Abbott (United States) (US) | |
| 7 | Katharine L. Chu | Abbott (United States) (US) | — |
| 8 | Kathy L. Kohlhaas | Abbott (United States) (US) | — |
| 9 | Marlon Cowart | Abbott (United States) (US) | — |
| 10 | Chih‐Hung Lee | Abbott (United States) (US) | |
| 11 | Andrew O. Stewart | Abbott (United States) (US) | — |
| 12 | Bryan F. Cox | Abbott (United States) (US) | — |
| 13 | James S. Polakowski | Abbott (United States) (US) | — |
| 14 | Elizabeth A. Kowaluk | Abbott (United States) (US) | — |
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