Cytosine arabinoside cerebrospinal fluid kinetics
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- DOI 10.1038/clpt.1984.120
- PMID https://pubmed.ncbi.nlm.nih.gov/6587957
- OpenAlex ID W2058326606
- Type Article
- Language EN
- Published 01 Jun 1984
- Volume 35 (6)
- Pages 826–830
- Source Clinical Pharmacology & Therapeutics
- Publisher Wiley
- FWCI 0.80
- Countries 2
- Institutions 4
- Added 10 Oct 2025
- Updated 01 Oct 2026
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Cytosine arabinoside cerebrospinal fluid kinetics
Article 1984 EN
To better characterize the disposition of cytosine arabinoside (Ara-C) in cerebrospinal fluid (CSF), its kinetics were studied in seven patients with meningeal leukemia in complete remission. After intraventricular injection of 30 mg Ara-C, CSF and plasma samples were obtained over a 24-hr period. Ara-C levels were measured by a reverse-phase HPLC assay (with a sensitivity of 0.5 microM in CSF and…
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1 SDGsAuthors & Affiliations
5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Solomon Zimm | National Institutes of Health (US) National Cancer Institute (UA) +2 | — |
| 2 | Jerry M. Collins | National Institutes of Health (US) National Cancer Institute (UA) +2 | |
| 3 | James S Miser | National Institutes of Health (US) National Cancer Institute (UA) +2 | |
| 4 | Dulal C. Chatterji | National Institutes of Health (US) National Cancer Institute (UA) +2 | — |
| 5 | David G. Poplack Corresponding | National Institutes of Health (US) National Cancer Institute (UA) +2 | — |
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