Prostaglandin Stimulation of Renin Release: Independence ofβ…

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Prostaglandin Stimulation of Renin Release: Independence ofβ-Adrenergic Receptor Activity and Possible Mechanism of Action*

Article 1980 EN

Using a continuous superfusion system of rat kidney cortical slices, we investigated the renin-releasing effect of prostaglandin E2 (PGE2) and its possible mechanism of action. PGE2 caused significant stimulation of renin release in a dose-dependent fashion at concentrations of 3 x 10(-6) to 10(-4) M. Isoproterenol (8 x 10(-7) M) stimulated renin release significantly, and its effect was completel…

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1 Roberto Franco-Saenz — —
2 Shin Suzuki —
3 S Y Tan —
4 Patrick J. Mulrow — —

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