BRIEF TREATMENT OF SHR WITH AN ACE INHIBITOR FAILS TO CAUSE LONG‐TERM NORMOTENSION BUT MARKEDLY INCREASES MORTALITY

1. We examined the effect of three doses (0.03, 0.3 and 3 mg/kg per day) of the angiotensin converting enzyme (ACE) inhibitor, perindopril, on the long-term blood pressure of spontaneously hypertensive rats (SHR) of the Okamoto strain after treatment during the developmental stage of hypertension development. 2. While the 0.03 mg/kg per day dose, given between the ages of 4-10 weeks of age, failed…