Intracerebroventricular Administration of Corticotrophin‐Releasing Hormone Receptor Antagonists Produces Different Effects on Hypothalamic Pituitary Adrenal Responses to Novel Restraint Depending on the Stress History of the Animal

Corticotrophin-releasing hormone (CRH) regulates acute stress-induced changes in neuroendocrine function and behaviour. However, little is known about CRH functions in animals that have prior experience with repeated stress. Repeatedly-stressed rats exhibit a habituated hypothalamic-pituitary-adrenal (HPA) response to a familiar, homotypic stressor but exhibit maintained or enhanced HPA responses…