FoxO Transcription Factors Promote AKT Ser473 Phosphorylatio…
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- DOI 10.1158/0008-5472.can-13-1729
- PMID https://pubmed.ncbi.nlm.nih.gov/24448243
- OpenAlex ID W2024933597
- Type Article
- Language EN
- Published 21 Jan 2014
- Volume 74 (6)
- Pages 1682–1693
- Source Cancer Research
- Publisher American Association for Cancer Res…
- FWCI 3.29
- Countries 1
- Institutions 1
- Added 10 Oct 2025
- Updated 24 Oct 2026
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FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway
Article 2014 EN Green
The PI3K-AKT pathway is hyperactivated in many human cancers, and several drugs to inhibit this pathway, including the PI3K/mTOR dual inhibitor NVP-BEZ235, are currently being tested in various preclinical and clinical trials. It has been shown that pharmacologic inhibition of the PI3K-AKT pathway results in feedback activation of other oncogenic signaling pathways, which likely will limit the cli…
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1 SDGsAuthors & Affiliations
6 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Aifu Lin | The University of Texas MD And… (US) | |
| 2 | Hai-long Piao | The University of Texas MD And… (US) | — |
| 3 | Zhuang Li | The University of Texas MD And… (US) | |
| 4 | Dos D. Sarbassov | The University of Texas MD And… (US) | |
| 5 | Li Ma | The University of Texas MD And… (US) | |
| 6 | Boyi Gan Corresponding | The University of Texas MD And… (US) |
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