Electron microscopic immunocytochemical localization of glucagon and pancreatic polypeptide in rat pancreas: Characterization of a population of islet cells containing both peptides

The distribution of glucagon and pancreatic polypeptide was studied immunocytochemically in rat pancreas at both light and electron microscopic levels. My earlier observation that these two peptides are distributed in three cell types--cells containing glucagon, cells containing pancreatic polypeptide, and cells containing both--was confirmed at the electron microscopic level. In the glucagon-panc…