Amyloidoses as seen by the Rheumatologist

Amyloidosis is due to extracellular deposition in various organs and tissues of amorphous materials made of protein fibrils, whose thickness is 10 nm. Seventeen different amyloid fibrils are known (1). Amyloidosis can be localised or systemic. There are 4 systemic amyloidoses (2): Familial amyloidosis with mutated transthyretin. Primary, paraprotein associated, amyloidosis AL. Secondary AA amyloid…