Transcription factors regulating the Na+/K+-ATPase genes

Na + /K + -ATPase is composed of two subunits named α and β. Each subunit has three isoforms of α1, α2 and α3 for α, β1, β2 and β3 for β (4,11,18,25). Expression of each isoform gene is regulated tissue specifically and developmentally (5,20,21). Each isoform has its unique affinities for ligands including Na + , K + and ATP and for an inhibitor ouabain (6,9,10). It is believed that any of the α i…