Effect of agonists of adenosine receptors on inflammatory markers in human Muller cells

We report the presence of adenosine receptors at molecular level and study their role in the inflammatory pathway under hyperglycemic condition. Human Muller cells were cultured in low (5 mM) and high (25 mM) glucose with 10 FBS and 1 P/S. Cells were starved in 0 FBS for 18 h and then treated with various agonists CCPA, CGS 21680, NECA and IB-MECA for 6, 12 and 24 h. The adenosine receptors were i…