Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) …

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1967
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  • PMID https://pubmed.ncbi.nlm.nih.gov/5227349
  • OpenAlex ID W1602394852
  • Type Article
  • Language EN
  • Published N/A
  • Volume 27 (3 Pt 2)
  • Pages 179–89
  • Source PubMed
  • Publisher National Institutes of Health
  • FWCI 0.95
  • Added 24 Jun 2016
  • Updated 31 Oct 2026
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Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and two related compounds on a spectrum of tumors.

Article 1967 EN

1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-methyl-1-nitrosourea (NSC-23909), and hydroxyurea (NSC-32065) were tested for antitumor activity against 31 transplantable animal tumors. BCNU, the most effective, produced complete inhibition of tumor growth in 16 tumors. Its antitumor action was generally the greatest at the maximum tolerated dose (MTD). Four rat tumors were completely inhibited by…

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UN Sustainable Development Goals
1 SDGs
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1 Kanematsu Sugiura Corresponding — —
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